av P Polakis · 2012 · Citerat av 807 — Given this pleiotropy, the relevance of the CBP mutations to Wnt signaling, per This is best defined by germline and somatic mutations in Wnt

25 Aug 2020 The F-statistics for the 125 and 254 SNPs predicting testosterone in men and women were all greater than 10, with mean 128.6 and 83.3,

‘Similarly, mutations within the Drosophila CBP homolog have wide-ranging pleiotropic phenotypes.’. More example sentences. ‘Many semidwarf mutants have pleiotropic effects on traits other than culm length.’. ‘Many mutants died or showed pleiotropic defects casting doubt on the specificity of their retinal phenotype and were not Definition of pleiotropic in the Definitions.net dictionary. Meaning of pleiotropic. What does pleiotropic mean?

Pleiotropic meaning

Antagonistically pleiotropic genes are the explanation for fitness trade-offs. This means that genes that are pleiotropic control for some beneficial traits and some detrimental traits; thus, if they happen to persist through natural selection, this will prevent organisms from reaching perfection because if they possess the benefits of the gene, they must also possess the imperfections or faults. Pleiotropy definition, the phenomenon of one gene being responsible for or affecting more than one phenotypic characteristic. See more. plei·o·trop·ic.

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Pleiotropy occurs when one gene influences multiple phenotypic traits. Consequently, a mutation in a pleiotropic gene may have an effect on some or all traits simultaneously.

12 Jul 2018 Pleiotropic effects—the effects of a genetic variant on multiple Valid instrumental variables are defined by three key assumptions (table 1, 11 Jun 2013 biological pleiotropy refers to a genetic variant or gene that has a direct biological assesses the significance of the pleiotropic index. A. And height is also a multi-factorial trait. What this means is that it's determined by multiple factors.

Define PLEIOTROPIC (adjective) and get synonyms. What is PLEIOTROPIC (adjective)? PLEIOTROPIC (adjective) meaning, pronunciation and more by Macmillan Dictionary

Definition of pleiotropic in English Turkish dictionary (Tıp, İlaç) Birden fazla etkisi olan bir gene veya mutasyona dair (Pisikoloji, Ruhbilim) pleyiotropikRelated Termspleiotropic gene (Biyoloji) Meaning of pleiotropy for the defined word. 문법적으로, 이 워드 "pleiotropy" 는 명사, 좀 더 구체적으로, 셀 수 있는 명사 및 단수로만 사용하는 명사. Pleiotropy means that a single gene affects two or more characters. In the context of life history evolution, pleiotropy means that a single gene affects the fitness Pleiotropy is a genetic disorder caused when one gene influences two or more apparently unrelated phenotypic traits. Explore more about Pleiotropy at BYJU'S. Pleiotropy is the well-established phenomenon of a single gene affecting multiple traits. It has long played a adjective.

It would be a mistake to attribute all beneficial outcomes obtained from statins solely to … plei·o·trop·ic. ( plī'ō-trop'ik ), Denoting, or characterized by, pleiotropy. Synonym (s): polyphenic. Farlex Partner Medical Dictionary © Farlex 2012.
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Jump to navigation Jump to search. English [] Adjective []. pleiotrophic.

What this means is that it's determined by multiple factors. Height can be determined by a person's genes, for example, but 8 Jul 2020 more characters is called pleiotropic gene. In human beings pleiotropy is exhibited by syndromes called sickle anaemia and phenylketonuria. 8 Feb 2021 Mutation in a pleiotropic gene may have an effect on several traits simultaneously He originally defined pleiotropy as occurring when "several 23 Jul 2019 Pleiotropic genes are those in which variation can cause observable change in two or more body systems that may often appear unrelated at Définition.
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Pleiotropic effects are the flipside of detrimental side effects. They may not be the reason to take the drug, but they may end up being a potentially significant part of the patient’s experience. Millions of people have taken various statins in many countries for years, so there is a wealth of data for epidemiological studies.

The word has been borrowed to the world of pharmacology where it is used to refer to actions of drugs that are not their main or intended action. Pleiotropic definition is - producing more than one effect; especially : having multiple phenotypic expressions. How to use pleiotropic in a sentence. Pleiotropy occurs when one gene influences two or more seemingly unrelated phenotypic traits.